Repurposed use of a currently available antibiotic and analogs to reduce alcohol consumption and negative alcohol-related consequences

Technology #d-1164

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Researchers
Susan Bergeson, Ph.D.
Through the use of bioinformatics technology applied to global mRNA and miRNA analyses of several genetic mouse models of alcohol consumption and dependence, Dr. Susan Bergeson's lab, together with her collaborators, have uncovered new genes and biological pathways not previously known to be involved in alcohol-related behaviors and responses.
External Link (www.ttuhsc.edu)
Peter Syapin, Ph.D.
Dr. Syapin's research interests include neurobiological underpinnings of alcohol abuse and alcoholism and the role of microglia and astrocytes in drug abuse.
External Link (www.ttuhsc.edu)
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David Snow
Director Intellectual Property 806-834-4989
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Provisional Patent Application Filed

Description:

The U.S. market for substance abuse treatment and diagnosis exceeds $3.1 billion annually, yet no effective drug treatment for alcoholism has been discovered that significantly reduces alcohol consumption.

Researchers have re-purposed the use of an FDA approved antibiotic currently available in the market that significantly reduces alcohol consumption in patients. The results of a mouse model study show a statistically significant reduction in alcohol consumption for groups treated with the described drug, with greater percent reductions expressed in males as compared to female subjects.  These data suggest that the anti-consumption activity of certain antibiotic derivatives stems from an effect in the central nervous system.

Reference Number: D-1164 

Market Applications:

  • Pharmaceuticals
  • Alcoholism Research 

Features, Benefits & Advantages:

  • Reduce alcohol consumption and alcohol-related side effects
  • Advance scientific understanding of antibiotic interactions with the central nervous system 

Intellectual Property: 

  • A U.S. Provisional Patent application, Serial 62/166,464 was filed on 5/26/15 for this invention.

Development Stage:

  • This invention has been reduced to practice in a murine model and research continues to further develop the technology. 

Researchers:

  • Susan Bergeson, Ph. D., Associate Professor, Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, Texas.
  • Peter Syapin, Ph. D., Professor, Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, Texas. 

Keywords: alcohol consumption, antibiotics, repurpose