Nematodes, especially C. elegans, have proven to be an effective model organism to investigate aging biology, neurodegenerative disorders, and age-related diseases. However, manual analysis of experiments related to the health and lifespan of nematodes can be highly labor-intensive, limiting experimental throughput.
This new microfluidic device offers a method to remove progeny while efficiently retaining the adult worms in the device. The multi-purpose device can be used to measure lifespan curves, record health span measures, conduct drug and RNAi assays, and quantify muscle strength as a function of age. The device also provides the ability to add or remove reagents at any point, enabling novel cross-sectional and longitudinal aging experiments.
Reference Number: D-1084
The technology can be utilized by scientists working with nematodes, especially those investigating aging biology, neurodegenerative disorders, and age-related diseases.
- Scientific Research
Features, Benefits & Advantages:
- Streamlines the nematode experimental process
- Provides a myriad of functions from a single device
- Ability to add or subtract reagents at any time
- Small footprint
A Provisional Patent Application, Serial 62/173,888 was filed on 6/10/15.
The inventors have produced and tested the invention.
Siva A. Vanapali, Ph.D., Whitacre College of Engineering, Department of Chemical Engineering, Texas Tech University , Lubbock, TX.
Mizanur Rahman, PhD candidate, Whitacre College of Engineering, Department of Chemical Engineering, Texas Tech University , Lubbock, TX.
Keywords: Caenorhaditis elegans, Microfluidic, aging, Lifespan, genetic screens