Cell Separation Microfluidic Device

Technology #d-1072

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Dr. Dimitri Pappas
Pappas is an associate professor in the Department of Chemistry & Biochemistry at Texas Tech. Previously serving as a senior scientist at Johnson Space Center, Pappas has earned national and international recognition for his work using new chemical methods to study and detect illnesses such as heart disease and cancer, and has been noted as one of the top bioanalytical chemists in the nation.
External Link (www.depts.ttu.edu)
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David McClure
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Provisional Patent Application Filed

PCT Patent Application Filed

This technology consists of a microdevice that separates blood cells based on differences in antigen expression. Cells of the same phenotype are separated based on their activation levels during infection and resting, thus enabling the microdevice to provide differential cell counts as a diagnostic tool for infections and inflammations. 


Market Applications:

  • Pharmaceuticals/Health Care
  • In Vitro Diagnostics


Features, Benefits & Advantages:

  • Provides differential cell counts in a short-time span
  • Allows for the quick identification of infections, particularly sepsis (a time critical diagnosis)
  • Implementable in any clinical setting due to ease of use and low cost


Development Stage:

A prototype has been produced and tested.  An IRB is pending approval to test human samples. 


Publications:

Cellular separations: a review of new challenges in analytical chemistry. Analytica chimica acta .11/2007; 601(1):26-35. DOI: 10.1016/j.aca.2007.08.0