There has been an increasing development of microfluidic-based, biomimetic organ-on-chip devices that allow researchers to perform stem cell research, regenerative medicine, and biomaterials and tissue engineering in three-dimensional in vitro models. A biomimetic heart system has been developed that simulates arterial flow, pulse properties and architectural environment as a cardiovascular research tool.
The BioCAV consists of four one-way valves and four fluidic pumps (two fluidic upper chambers and two lower fluidic chambers) to mimic atria and ventricles, respectively. During the simulation of blood circulation, fluid (blood) passes through the valves to fill each chamber of the chip, thus mimicking a beating heart. After blood passes through the open valves, backward flow is prevented with closure of the one-way valves, which precisely mimics the valvular mechanical environment. With the BioCAV, heart valve functions such as pumping frequency, loading volume and distribution of mechano-chemical signals can be mimicked in vitro to understand the progression of valvular disease and the parameters that culminate in heart failure.
- Disease mechanism studies
- Heart valve disease modeling for personalized healthcare
- Absorption, Distribution, Metabolism, and Excretion (ADME) testing sector in the fields of photokinetics and pharmacology
Features, Benefits, and Advantages:
- System can serve as a tool for multiple applications in pharmaceutical compound screening, disease mechanism studies, and personalized healthcare
- Mimics arterial flow, pulse properties, and architectural cardiac environment
This technology has been produced and tested. Work on this invention is ongoing.